BMH2 14-3-3 family protein BMH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BMH2
Official Full Name: 14-3-3 family protein BMH2
Primary source: SGD:S000002506
Locus tag: YDR099W
See related: AllianceGenome:SGD:S000002506; FungiDB:YDR099W; VEuPathDB:YDR099W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SCD3
Summary: Enables DNA replication origin binding activity and phosphoserine residue binding activity. Involved in several processes, including DNA-templated DNA replication; chitin biosynthetic process; and intracellular signal transduction. Located in cytoplasm and nucleus. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BMH2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (653607..654428)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
Title: Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84
Title: Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.
Both Bmh1 and Bmh2 associate with the promoters of at least some of these genes. BMH2, but not BMH1, attenuates the repression of genes involved in some functions required for ribosome biogenesis. BMH2 also attenuates the activation of genes sensitive to nitrogen catabolite repression.
Title: The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription.
Bmh2 is required for nuclear Gln3 localization and appears to function downstream of Ure2.
Title: General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization.
demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
Title: Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
Data indicate that transcription activation is regulated negatively by two redundant 14-3-3 isoforms, Bmh1 and Bmh2.
Title: Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.
Bmh1 and Bmh2 inhibit transcription by binding to Adr1 at promoters that contain a preinitiation complex, demonstrating that Bmh-mediated inhibition is not due to nuclear exclusion, inhibition of DNA binding, or RNA polymerase II (Pol II) recruitment.
Title: 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.
Yeast BMH1 and BMH2 possess a distinctly variant C-terminal compared to human 14-3-3 zeta protein.
Title: The C-terminal segment of yeast BMH proteins exhibits different structure compared to other 14-3-3 protein isoforms.
BMH2 function as essential factors for the assembly and maintenance of the pre-replication complex during G1 phase.
Title: 14-3-3 proteins function in the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae.
Nucleocytoplasmic shuttling of Pik1p involves phosphorylation and 14-3-3 proteins bind Pik1p in the cytoplasm.
Title: Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoserine residue binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ascospore formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chitin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cell cycle	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IPI Inferred from Physical Interaction more info	PubMed
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in pseudohyphal growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of glycogen metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction involved in filamentous growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: 14-3-3 family protein BMH2

NP_010384.3

14-3-3 protein, minor isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates multiple processes including exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; abundance relative to Bmh1p increases during sporulation; similar to several human 14-3-3 proteins