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    NUP42 FG-nucleoporin NUP42 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUP42
    Official Full Name
    FG-nucleoporin NUP42
    Primary source
    SGD:S000002600
    Locus tag
    YDR192C
    See related
    AllianceGenome:SGD:S000002600; FungiDB:YDR192C; VEuPathDB:YDR192C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RIP1; UIP1
    Summary
    A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Part of nuclear pore central transport channel and nuclear pore cytoplasmic filaments. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUP42 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (843569..844861, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene RuvB family ATP-dependent DNA helicase pontin Neighboring gene NAD-dependent histone deacetylase HST4 Neighboring gene ATP-dependent RNA helicase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast. Stutz F, et al. Cell, 1995 Aug 11. PMID 7634338
    2. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Jensen TH, et al. Mol Cell, 2001 Apr. PMID 11336711
    3. Cellular memory of acquired stress resistance in Saccharomyces cerevisiae. Guan Q, et al. Genetics, 2012 Oct. PMID 22851651, Free PMC Article
    4. Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways. Vainberg IE, et al. Mol Cell Biol, 2000 Jun. PMID 10805742, Free PMC Article
    5. T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export. Dower K, et al. RNA, 2002 May. PMID 12022234, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA export from nucleus in response to heat stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore cytoplasmic filaments IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FG-nucleoporin NUP42
    NP_010478.3
    • FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p; human homolog NUP42 can complement yeast mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      843569..844861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180500.3 → NP_010478.3  TPA: FG-nucleoporin NUP42 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010478.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSH5, P49686
      UniProtKB/TrEMBL
      B5VG86, C7GN05, N1P4X4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49686.1

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