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    EAF5 Eaf5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EAF5
    Official Full Name
    Eaf5p
    Primary source
    SGD:S000000744
    Locus tag
    YEL018W
    See related
    AllianceGenome:SGD:S000000744; FungiDB:YEL018W; VEuPathDB:YEL018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA repair. Located in cytosol and nucleus. Part of NuA4 histone acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EAF5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (121471..122310)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative indolepyruvate decarboxylase family protein Neighboring gene SUMO ligase MMS21 Neighboring gene proteolipid ATPase Neighboring gene Gtt3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction. Dalwadi U, et al. Mol Cell Biol, 2022 Nov 17. PMID 36190236, Free PMC Article
    2. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Nourani A, et al. Mol Cell Biol, 2001 Nov. PMID 11604499, Free PMC Article
    3. Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins. Tanaka S. Genetics, 2021 Mar 3. PMID 33683348, Free PMC Article
    4. NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Ginsburg DS, et al. Mol Cell Biol, 2009 Dec. PMID 19822662, Free PMC Article
    5. Structure of the NuA4 histone acetyltransferase complex. Ji L, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36417436, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro binding assays showed that Eaf3/5/7 specifically stimulates NuA4 binding to di- and trimethylated histone H3 Lys-36 and that this binding is important for NuA4 occupancy in transcribed ORFs.
      Title: The Eaf3/5/7 Subcomplex Stimulates NuA4 Interaction with Methylated Histone H3 Lys-36 and RNA Polymerase II.
    2. Eaf5 and Eaf7 form a subcomplex. Eaf7 interacts with NuA4 through Eaf5.
      Title: Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eaf5p
    NP_010897.1
    • Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      121471..122310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178833.1 → NP_010897.1  TPA: Eaf5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLN1, P39995
      UniProtKB/TrEMBL
      A6ZQT1, B3LRZ8, B5VHB9, C7GX25, C8Z6Y1, G2WCL4, N1PA76
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39995.1

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