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    EPL1 Epl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EPL1
    Official Full Name
    Epl1p
    Primary source
    SGD:S000001870
    Locus tag
    YFL024C
    See related
    AllianceGenome:SGD:S000001870; FungiDB:YFL024C; VEuPathDB:YFL024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to histone acetyltransferase activity. Involved in DNA repair; positive regulation of macroautophagy; and regulation of transcription by RNA polymerase II. Part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex. Orthologous to several human genes including EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EPL1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (87847..90345, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene alpha-factor pheromone receptor STE2 Neighboring gene Bst1p Neighboring gene Bud27p Neighboring gene phenylalanine--tRNA ligase subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Selleck W, et al. Mol Cell Biol, 2005 Jul. PMID 15964809, Free PMC Article
    2. Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Berndsen CE, et al. Biochemistry, 2007 Feb 27. PMID 17274630, Free PMC Article
    3. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Searle NE, et al. Genetics, 2017 Mar. PMID 28108589, Free PMC Article
    4. A simple and effective set of PCR-based molecular markers for the monitoring of the Saccharomyces cerevisiae cell population during bioethanol fermentation. Carvalho-Netto OV, et al. J Biotechnol, 2013 Dec. PMID 23994268
    5. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism. Xu P, et al. Mol Cell, 2016 Sep 15. PMID 27594449

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epl1 domains required in vivo for interaction with specific NuA4 subunits, histone acetylation, and chromatin targeting were identified.
      Title: Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.
    2. Data suggest that substrate specificity of Piccolo NuA4 (NuA4/Epl1/Yng2 histone acetyltransferase complex) includes acetylation of histone tetramers (H3/H4)2 and nucleosome core particles.
      Title: Site specificity analysis of Piccolo NuA4-mediated acetylation for different histone complexes.
    3. Epl1 EPcA basic region is in proximity to the N-terminal histone H2A tail, the globular region of histone H4, and also to nucleosomal DNA when Piccolo NuA4 interacts with the nucleosome.
      Title: Piccolo NuA4-catalyzed acetylation of nucleosomal histones: critical roles of an Esa1 Tudor/chromo barrel loop and an Epl1 enhancer of polycomb A (EPcA) basic region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of piccolo histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Epl1p
    NP_116629.1
    • Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      87847..90345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179942.1 → NP_116629.1  TPA: Epl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK6, P43572
      UniProtKB/TrEMBL
      B3LUI7, C8Z7Q9, G2WDB7, N1P4X2
      Conserved Domains (1) summary
      pfam10513
      Location:56 → 197
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43572.1

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