U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HOS2 histone deacetylase HOS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852681, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HOS2
    Official Full Name
    histone deacetylase HOS2
    Primary source
    SGD:S000003162
    Locus tag
    YGL194C
    See related
    AllianceGenome:SGD:S000003162; FungiDB:YGL194C; VEuPathDB:YGL194C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RTL1
    Summary
    Enables NAD-independent histone deacetylase activity. Involved in negative regulation of meiotic nuclear division; positive regulation of stress-activated MAPK cascade; and regulation of DNA-templated transcription. Acts upstream of or within positive regulation of translation. Located in nuclear periphery. Part of Set3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HOS2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (140368..141726, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Gcn1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mRNA (N6-adenosine)-methyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RNA Polymerase II Dependent Crosstalk between H4K16 Deacetylation and H3K56 Acetylation Promotes Transcription of Constitutively Expressed Genes. Khan P, et al. Mol Cell Biol, 2023. PMID 37937370, Free PMC Article
    2. SUB1 Plays a Negative Role during Starvation Induced Sporulation Program in Saccharomyces cerevisiae. Gupta R, et al. PLoS One, 2015. PMID 26147804, Free PMC Article
    3. Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery. Lin WH, et al. Nucleic Acids Res, 2024 Jul 22. PMID 38783136, Free PMC Article
    4. Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae. Matsumoto T, et al. PLoS One, 2011 Jan 28. PMID 21297980, Free PMC Article
    5. Polyamines inhibit the yeast histone deacetylase. Vu QA, et al. FEBS Lett, 1987 Aug 10. PMID 3301411

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II.
      Title: Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.
    2. observed the formation of a reversible cytosolic "stationary-phase granule" by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability.
      Title: The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells.
    3. both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes
      Title: Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae.
    4. the Hos2p/Set3p complex (SET3C) is a novel component critical for cell survival in response to secretory stress.
      Title: Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway.
    5. Two histone deacetylases, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1.
      Title: Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes.
    6. Hos2 and Set3 function at tRNA genes to promote Ty1 integration
      Title: Hos2 and Set3 promote integration of Ty1 retrotransposons at tRNA genes in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone H3K14 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    histone deacetylase HOS2
    NP_011321.1
    • Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      140368..141726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181059.1 → NP_011321.1  TPA: histone deacetylase HOS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTW0, P53096
      UniProtKB/TrEMBL
      A6ZTZ5, B3LHP2, C7GX01, G2WDR3, N1P6D2
      Conserved Domains (1) summary
      cd11598
      Location:28 → 338
      HDAC_Hos2; Class I histone deacetylases including ScHos2 and SpPhd1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53096.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.