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    RME1 Rme1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852935, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RME1
    Official Full Name
    Rme1p
    Primary source
    SGD:S000003276
    Locus tag
    YGR044C
    See related
    AllianceGenome:SGD:S000003276; FungiDB:YGR044C; VEuPathDB:YGR044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CSP1
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of invasive growth in response to glucose limitation; and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RME1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (582990..583892, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mte1p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 Neighboring gene uncharacterized protein Neighboring gene putative phosphatidate cytidylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of mating and meiosis in yeast by the mating-type region. Kassir Y, et al. Genetics, 1976 Feb. PMID 770230, Free PMC Article
    2. Intercalation of a new tier of transcription regulation into an ancient circuit. Booth LN, et al. Nature, 2010 Dec 16. PMID 21164485, Free PMC Article
    3. Repression and activation domains of RME1p structurally overlap, but differ in genetic requirements. Blumental-Perry A, et al. Mol Biol Cell, 2002 May. PMID 12006664, Free PMC Article
    4. Rme1, which controls CLN2 expression in Saccharomyces cerevisiae, is a nuclear protein that is cell cycle regulated. Frenz LM, et al. Mol Genet Genomics, 2001 Nov. PMID 11713667
    5. A C-terminal segment with properties of alpha-helix is essential for DNA binding and in vivo function of zinc finger protein Rme1p. Shimizu M, et al. J Biol Chem, 2001 Oct 5. PMID 11466318

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rme1p
    NP_011558.1
    • Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      582990..583892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181173.1 → NP_011558.1  TPA: Rme1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI2, P32338, Q45TA6
      UniProtKB/TrEMBL
      A6ZV32, B3LIH7, B5VIZ7, B8XW44, C7GXN0, C8Z8U0, G2WED4, Q45T98, Q45TA4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32338.1

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