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    HSE1 ESCRT-0 subunit protein HSE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HSE1
    Official Full Name
    ESCRT-0 subunit protein HSE1
    Primary source
    SGD:S000000994
    Locus tag
    YHL002W
    See related
    AllianceGenome:SGD:S000000994; FungiDB:YHL002W; VEuPathDB:YHL002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin binding activity. Involved in ATP export; microautophagy; and vacuolar transport. Located in endosome and vacuolar membrane. Part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule) and STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HSE1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (102612..103970)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRP4 Neighboring gene sphingosine N-acyltransferase LAG1 Neighboring gene ribosomal 60S subunit protein L14B Neighboring gene oxysterol-binding protein related protein OSH7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution and origin of HRS, a protein interacting with Merlin, the Neurofibromatosis 2 gene product. Omelyanchuk LV, et al. Gene Regul Syst Bio, 2009 Oct 8. PMID 20054405, Free PMC Article
    2. Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting. Han S, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24607902
    3. TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast. Morshed S, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31740006
    4. The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Prag G, et al. Dev Cell, 2007 Jun. PMID 17543868, Free PMC Article
    5. The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Bilodeau PS, et al. Nat Cell Biol, 2002 Jul. PMID 12055639

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
      Title: TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
    2. Small-angle X-ray scattering combined with molecular docking and biochemical analysis yield the solution structure of the Doa1/PFU:Hse1/SH3 complex and suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.
      Title: Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting.
    3. Endosomal Hse1-Vps27 sorting receptor binds to ubiquitin peptidases and the ubiquitin ligase Rsp5.
      Title: Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT-0 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ESCRT-0 subunit protein HSE1
    NP_011861.1
    • Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      102612..103970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179082.1 → NP_011861.1  TPA: ESCRT-0 subunit protein HSE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR2, P38753
      UniProtKB/TrEMBL
      A6ZSQ0, B3LSB6, C7GX96, C8ZA64, G2WF64, N1P2N8
      Conserved Domains (3) summary
      cd11805
      Location:221 → 273
      SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
      cd16978
      Location:8 → 140
      VHS_HSE1; VHS (Vps27/Hrs/STAM) domain of Class E vacuolar protein-sorting machinery protein HSE1
      cd21386
      Location:290 → 374
      GAT_Hse1; non-canonical GAT domain found in fungal class E vacuolar protein-sorting machinery protein Hse1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38753.1

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