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    GOS1 Gos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GOS1
    Official Full Name
    Gos1p
    Primary source
    SGD:S000001023
    Locus tag
    YHL031C
    See related
    AllianceGenome:SGD:S000001023; FungiDB:YHL031C; VEuPathDB:YHL031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity. Involved in Golgi vesicle transport and vesicle fusion. Located in Golgi medial cisterna. Part of SNARE complex. Orthologous to human GOSR1 (golgi SNAP receptor complex member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GOS1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (38815..39486, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L8A Neighboring gene glycerol kinase Neighboring gene Ecm29p Neighboring gene Oca5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Live imaging of yeast Golgi cisternal maturation. Matsuura-Tokita K, et al. Nature, 2006 Jun 22. PMID 16699523
    2. Crystallization and preliminary X-ray diffraction analysis of Gos1p, a yeast SNARE protein. Cheng B, et al. Acta Crystallogr F Struct Biol Commun, 2014 Jul. PMID 25005100, Free PMC Article
    3. Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies. Völker JM, et al. Dis Model Mech, 2017 Dec 19. PMID 28982678, Free PMC Article
    4. Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport. McNew JA, et al. FEBS Lett, 1998 Sep 11. PMID 9755865
    5. Three-dimensional and immune electron microscopic analysis of the secretory pathway in Saccharomyces cerevisiae. Beznoussenko GV, et al. Histochem Cell Biol, 2016 Nov. PMID 27590193

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of the truncated forms of Gos1 has been determined.
      Title: Crystallization and preliminary X-ray diffraction analysis of Gos1p, a yeast SNARE protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inter-Golgi cisterna vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi medial cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gos1p
    NP_011832.1
    • v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      38815..39486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179111.1 → NP_011832.1  TPA: Gos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT7, P38736
      UniProtKB/TrEMBL
      A6ZSL9, B3LS88, B5VJP8, C7GIQ5, G2WF34, N1P237
      Conserved Domains (1) summary
      pfam12352
      Location:136 → 201
      V-SNARE_C; Snare region anchored in the vesicle membrane C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38736.1

    Gene LinkOut

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