DOG2 2-deoxyglucose-6-phosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: DOG2
Official Full Name: 2-deoxyglucose-6-phosphatase
Primary source: SGD:S000001085
Locus tag: YHR043C
See related: AllianceGenome:SGD:S000001085; FungiDB:YHR043C; VEuPathDB:YHR043C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 2-deoxyglucose-6-phosphatase activity. Involved in glucose metabolic process. Located in cytoplasm and nucleus. Used to study cancer. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
Title: The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-deoxyglucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-deoxyglucose-6-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-deoxyglucose-6-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_011909.1

2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae

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The following sections contain reference sequences that belong to a specific genome build. Explain