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    MED6 mediator complex subunit MED6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED6
    Official Full Name
    mediator complex subunit MED6
    Primary source
    SGD:S000001100
    Locus tag
    YHR058C
    See related
    AllianceGenome:SGD:S000001100; FungiDB:YHR058C; VEuPathDB:YHR058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MED6 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (218997..219884, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rsc30p Neighboring gene peptidylprolyl isomerase CPR2 Neighboring gene mitochondrial 37S ribosomal protein FYV4 Neighboring gene Vma22p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Kim GS, et al. Biochem Res Int, 2018. PMID 29992056, Free PMC Article
    2. Srb7p is a physical and physiological target of Tup1p. Gromöller A, et al. EMBO J, 2000 Dec 15. PMID 11118219, Free PMC Article
    3. Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. Gustafsson CM, et al. J Biol Chem, 1997 Jan 3. PMID 8995225
    4. Different upstream transcriptional activators have distinct coactivator requirements. Lee DK, et al. Genes Dev, 1999 Nov 15. PMID 10580000, Free PMC Article
    5. Functional and physical interactions within the middle domain of the yeast mediator. Hallberg M, et al. Mol Genet Genomics, 2006 Aug. PMID 16758199

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit MED6
    NP_011925.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      218997..219884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179188.1 → NP_011925.1  TPA: mediator complex subunit MED6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL07, P38782
      UniProtKB/TrEMBL
      A6ZSW4, G2WFD0, N1P9D1
      Conserved Domains (1) summary
      COG5097
      Location:1 → 283
      MED6; RNA polymerase II transcriptional regulation mediator [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38782.1

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