FMO1 N,N-dimethylaniline monooxygenase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FMO1
Official Full Name: N,N-dimethylaniline monooxygenase
Primary source: SGD:S000001219
Locus tag: YHR176W
See related: AllianceGenome:SGD:S000001219; FungiDB:YHR176W; VEuPathDB:YHR176W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables N,N-dimethylaniline monooxygenase activity. Involved in protein folding. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO1 (flavin containing dimethylaniline monoxygenase 1); FMO2 (flavin containing dimethylaniline monoxygenase 2); and FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

NP_012046.4

Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins

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The following sections contain reference sequences that belong to a specific genome build. Explain