RPC17 DNA-directed RNA polymerase III subunit RPC17 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPC17
Official Full Name: DNA-directed RNA polymerase III subunit RPC17
Primary source: SGD:S000003548
Locus tag: YJL011C
See related: AllianceGenome:SGD:S000003548; FungiDB:YJL011C; VEuPathDB:YJL011C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Located in cytosol and nucleus. Part of RNA polymerase III complex. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPC17 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (414285..414770, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.
Title: Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.
Crystal structure of subunit C17 is determined.
Title: Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase III promoter	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC17

NP_012523.2

RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

414285..414770 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181445.2 → NP_012523.2 TPA: DNA-directed RNA polymerase III subunit RPC17 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012523.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWG6, P47076

UniProtKB/TrEMBL

A6ZPV8, B3LQ91, B5VLG1, C7GSP2, C8ZBK0, G2WH00, N1P8K7

Conserved Domains (1) summary

pfam03874
Location:10 → 160

RNA_pol_Rpb4; RNA polymerase Rpb4