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    ACO2 aconitate hydratase ACO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ACO2
    Official Full Name
    aconitate hydratase ACO2
    Primary source
    SGD:S000003736
    Locus tag
    YJL200C
    See related
    AllianceGenome:SGD:S000003736; FungiDB:YJL200C; VEuPathDB:YJL200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ACO2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (56444..58813, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Prp21p Neighboring gene Ecm25p Neighboring gene tRNA-Thr Neighboring gene Mbb1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5-Aminolevulinic acid fermentation using engineered Saccharomyces cerevisiae. Hara KY, et al. Microb Cell Fact, 2019 Nov 7. PMID 31699086, Free PMC Article
    2. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. Bradley PH, et al. mSystems, 2019 Jan-Feb. PMID 30834327, Free PMC Article
    3. Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. van den Berg MA, et al. Yeast, 1998 Sep 15. PMID 9778795
    4. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Natarajan K, et al. Mol Cell Biol, 2001 Jul. PMID 11390663, Free PMC Article
    5. The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate. Fazius F, et al. Mol Microbiol, 2012 Dec. PMID 23106124, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aconitate hydratase ACO2
    NP_012335.1
    • Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      56444..58813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181633.1 → NP_012335.1  TPA: aconitate hydratase ACO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012335.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ3, P39533
      UniProtKB/TrEMBL
      C7GUF3, C8ZB20, G2WGH9
      Conserved Domains (1) summary
      TIGR01340
      Location:35 → 782
      aconitase_mito; aconitate hydratase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39533.1

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