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    MCM22 Mcm22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCM22
    Official Full Name
    Mcm22p
    Primary source
    SGD:S000003896
    Locus tag
    YJR135C
    See related
    AllianceGenome:SGD:S000003896; FungiDB:YJR135C; VEuPathDB:YJR135C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation and establishment of mitotic sister chromatid cohesion. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCM22 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (676059..676778, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene xanthine phosphoribosyltransferase Neighboring gene Sgm1p Neighboring gene protein transporter TIM8 Neighboring gene Tti2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission. Poddar A, et al. Mol Microbiol, 1999 Jan. PMID 9987135
    2. The structure of the yeast Ctf3 complex. Hinshaw SM, et al. Elife, 2019 Jun 13. PMID 31194673, Free PMC Article
    3. The budding yeast protein Sum1 functions independently of its binding partners Hst1 and Sir2 histone deacetylases to regulate microtubule assembly. Sarkar S, et al. FEMS Yeast Res, 2010 Sep. PMID 20608984
    4. Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. Zhang Z, et al. Nucleic Acids Res, 2020 Nov 4. PMID 32976599, Free PMC Article
    5. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Ghosh SK, et al. Mol Genet Genomics, 2001 Apr. PMID 11361335

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mcm22p
    NP_012669.1
    • Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      676059..676778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181793.1 → NP_012669.1  TPA: Mcm22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV3, P47167
      UniProtKB/TrEMBL
      A6ZQ90, B3LQL7, B5VLS4, C7GM78, C8ZBT3, G2WHD7, N1P1T2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47167.1

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