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    THI11 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI11
    Official Full Name
    4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
    Primary source
    SGD:S000003917
    Locus tag
    YJR156C
    See related
    AllianceGenome:SGD:S000003917; FungiDB:YJR156C; VEuPathDB:YJR156C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity and transferase activity. Involved in thiamine biosynthetic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI11 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (728574..729596, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative aryl-alcohol dehydrogenase Neighboring gene hexose transporter HXT16 Neighboring gene L-iditol 2-dehydrogenase SOR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
    2. The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Wightman R, et al. Microbiology (Reading), 2003 Jun. PMID 12777485
    3. Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Rodríguez-Navarro S, et al. Yeast, 2002 Oct. PMID 12271461
    4. Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. Batisse J, et al. J Biol Chem, 2009 Dec 11. PMID 19840948, Free PMC Article
    5. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan NJ, et al. Nature, 2006 Mar 30. PMID 16554755

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
    NP_012690.3
    • Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      728574..729596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181814.3 → NP_012690.3  TPA: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012690.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX5, P47183
      UniProtKB/TrEMBL
      C8ZBV6, C8ZGJ3
      Conserved Domains (1) summary
      cd13650
      Location:5 → 255
      PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47183.1

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