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    FPT1 chromatin-associated RNAPIII regulator FPT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FPT1
    Official Full Name
    chromatin-associated RNAPIII regulator FPT1
    Primary source
    SGD:S000001719
    Locus tag
    YKR011C
    See related
    AllianceGenome:SGD:S000001719; FungiDB:YKR011C; VEuPathDB:YKR011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tDNA binding activity. Involved in cellular response to nutrient levels and negative regulation of RNA polymerase III activity. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FPT1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (461635..462696, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Tof2p Neighboring gene sterol-binding protein Neighboring gene Rab family GTPase YPT52

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly. van Breugel ME, et al. Mol Cell, 2023 Dec 7. PMID 37995691, Free PMC Article
    2. Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters. Hogan GJ, et al. PLoS Genet, 2006 Sep 22. PMID 17002501, Free PMC Article
    3. Deletion of 24 open reading frames from chromosome XI from Saccharomyces cerevisiae and phenotypic analysis of the deletants. Zúñiga S, et al. Gene, 1999 Jun 11. PMID 10375630
    4. The Rtt106 histone chaperone is functionally linked to transcription elongation and is involved in the regulation of spurious transcription from cryptic promoters in yeast. Imbeault D, et al. J Biol Chem, 2008 Oct 10. PMID 18708354
    5. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables tDNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of RNA polymerase III activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    chromatin-associated RNAPIII regulator FPT1
    NP_012936.1
    • Chromatin-associated negative regulator of RNA polymerase III assembly; differentially and dynamically occupies RNA polymerase III-transcribed genes; promotes eviction of RNAPIII; occupancy depends on TFIIIB and TFIIIC, not RNAPIII; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      461635..462696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179801.1 → NP_012936.1  TPA: chromatin-associated RNAPIII regulator FPT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX77, Q02209
      UniProtKB/TrEMBL
      A6ZZX6, B3LR96, B5VMF9, C7GNP6, G2WI43, N1P0V2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02209.2

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