HEL1 E3 ubiquitin-protein ligase HEL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HEL1
Official Full Name: E3 ubiquitin-protein ligase HEL1
Primary source: SGD:S000001725
Locus tag: YKR017C
See related: AllianceGenome:SGD:S000001725; FungiDB:YKR017C; VEuPathDB:YKR017C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin protein ligase activity. Involved in histone catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HEL1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (471694..473349, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3 ubiquitin ligases such as Hel1(YKR017C)to ensure excess histone degradation and thus contribute to the maintenance of genomic stability.
Title: Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in histone catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HEL1

NP_012942.3

EC 2.3.2.31

RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

471694..473349 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179807.3 → NP_012942.3 TPA: E3 ubiquitin-protein ligase HEL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012942.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX82, P36113

UniProtKB/TrEMBL

A6ZZY1, B3LRA1, B5VMG4, C7GNP2, C8ZCI1, G2WI48, N1P2M7

Conserved Domains (2) summary

cd16625
Location:177 → 222

RING-HC_RBR_HEL2_like; RING finger, HC subclass, found in Saccharomyces cerevisiae histone E3 ligase 2 (HEL2) and similar proteins

pfam01485
Location:342 → 374

IBR; IBR domain, a half RING-finger domain