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    VPS51 Vps51p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS51
    Official Full Name
    Vps51p
    Primary source
    SGD:S000001728
    Locus tag
    YKR020W
    See related
    AllianceGenome:SGD:S000001728; FungiDB:YKR020W; VEuPathDB:YKR020W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    API3; VPS67; WHI6
    Summary
    Involved in several processes, including budding cell apical bud growth; intracellular sphingolipid homeostasis; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. Part of GARP complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS51 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (478338..478832)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Irs4p Neighboring gene Aly1p Neighboring gene Ntr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of the interaction between the SNARE Tlg1 and Vps51. Fridmann-Sirkis Y, et al. Traffic, 2006 Feb. PMID 16420526
    2. Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. Markovich S, et al. Antimicrob Agents Chemother, 2004 Oct. PMID 15388447, Free PMC Article
    3. Yeast dynamin associates with the GARP tethering complex for endosome-to-Golgi traffic. Saimani U, et al. Eur J Cell Biol, 2017 Sep. PMID 28521960
    4. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy. Tsai HJ, et al. Nature, 2019 Jun. PMID 31068692, Free PMC Article
    5. Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Bugnicourt A, et al. Traffic, 2008 May. PMID 18298591

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in budding cell apical bud growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell size HMP PubMed 
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GARP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps51p
    NP_012945.1
    • Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      478338..478832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179810.1 → NP_012945.1  TPA: Vps51p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX85, P36116
      UniProtKB/TrEMBL
      A6ZZY4, B3LRA4, C7GNN9, C8ZCI4, G2WI51, N1P820
      Conserved Domains (1) summary
      pfam08700
      Location:92 → 155
      Vps51; Vps51/Vps67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36116.1

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