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    SDC25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDC25
    Primary source
    SGD:S000003939
    Locus tag
    YLL016W
    See related
    AllianceGenome:SGD:S000003939; FungiDB:YLL016W; VEuPathDB:YLL016W
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell division and small GTPase-mediated signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDC25 in Genome Data Viewer
    Location:
    chromosome: XII
    Sequence:
    Chromosome: XII; NC_001144.5 (112847..115993)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene aspartate--tRNA ligase DPS1 Neighboring gene pseudo Neighboring gene ATP-binding cassette bilirubin transporter BPT1 Neighboring gene Emc6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved structural motifs in cyclins identified by sequence analysis. Nugent JH, et al. J Cell Sci, 1991 Jul. PMID 1834684
    2. The COOH-domain of the product of the Saccharomyces cerevisiae SCD25 gene elicits activation of p21-ras proteins in mammalian cells. Rey I, et al. Oncogene, 1991 Feb. PMID 2000228
    3. Inhibition of SDC25 C-domain-induced guanine-nucleotide exchange by guanine ring binding domain mutants of v-H-ras. Hwang YW, et al. J Biol Chem, 1993 Nov 25. PMID 8227029
    4. A new function of p120-GTPase-activating protein. Prevention of the guanine nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21. Giglione C, et al. J Biol Chem, 1997 Oct 3. PMID 9312123
    5. The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17. Schweighoffer F, et al. Mol Cell Biol, 1993 Jan. PMID 8380225, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    • Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    Gene LinkOut

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    Other Literature Sources
    Research Materials