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    CCW12 Ccw12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCW12
    Official Full Name
    Ccw12p
    Primary source
    SGD:S000004100
    Locus tag
    YLR110C
    See related
    AllianceGenome:SGD:S000004100; FungiDB:YLR110C; VEuPathDB:YLR110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cell wall. Involved in agglutination involved in conjugation with cellular fusion and fungal-type cell wall organization. Located in cellular bud tip and mating projection tip. Is active in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCW12 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (369697..370098, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thioredoxin peroxidase AHP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Ccw12p, a major key player in cell wall stability of Saccharomyces cerevisiae. Ragni E, et al. Yeast, 2007 Apr. PMID 17315267
    2. Mapping HA-tagged protein at the surface of living cells by atomic force microscopy. Formosa C, et al. J Mol Recognit, 2015 Jan. PMID 26046654
    3. Characterization of two new genes down-regulated by alpha-factor. Seidel J, et al. Yeast, 1997 Jul. PMID 9234669
    4. Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain. Inokuma K, et al. Appl Microbiol Biotechnol, 2021 Aug. PMID 34272577
    5. Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein. Shankarnarayan S, et al. J Biol Chem, 2008 Jan 25. PMID 18048366, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ccw12p is necessary to ensure cell wall integrity, especially during bud emergence and formation of the mating projection.
      Title: The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections.
    2. Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
      Title: Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
    3. major role in cell wall stability.
      Title: Characterization of Ccw12p, a major key player in cell wall stability of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cell wall IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in agglutination involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ccw12p
    NP_013211.1
    • Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      369697..370098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181997.1 → NP_013211.1  TPA: Ccw12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB0, Q12127
      UniProtKB/TrEMBL
      A7A114, B3LT77, C7GQT2, C8ZD81, G2WIV4, N1NY69
      Conserved Domains (1) summary
      pfam13928
      Location:32 → 75
      Flocculin_t3; Flocculin type 3 repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12127.1

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