UBC12 NEDD8-conjugating protein UBC12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UBC12
Official Full Name: NEDD8-conjugating protein UBC12
Primary source: SGD:S000004297
Locus tag: YLR306W
See related: AllianceGenome:SGD:S000004297; FungiDB:YLR306W; VEuPathDB:YLR306W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NEDD8 transferase activity. Involved in protein neddylation. Predicted to be active in cytosol and nucleus. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See UBC12 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 2

Sequence:: Chromosome: XII; NC_001144.5 (744151..744851)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NEDD8 conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables NEDD8 transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NEDD8 transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NEDD8-conjugating protein UBC12

NP_013409.1

EC 2.3.2.34

Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

744151..744851

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182194.1 → NP_013409.1 TPA: NEDD8-conjugating protein UBC12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013409.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYU9, P52491

UniProtKB/TrEMBL

A7A1J0, B3RHI4, C7GUC5, G2WJC8

Conserved Domains (1) summary

COG5078
Location:26 → 178

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]