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    COX14 Cox14p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX14
    Official Full Name
    Cox14p
    Primary source
    SGD:S000004598
    Locus tag
    YML129C
    See related
    AllianceGenome:SGD:S000004598; FungiDB:YML129C; VEuPathDB:YML129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly and negative regulation of mitochondrial translation. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX14 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (14541..14753, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ER oxidoreductin Neighboring gene Msc1p Neighboring gene Rsc9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of COX14, whose product is required for assembly of yeast cytochrome oxidase. Glerum DM, et al. J Biol Chem, 1995 Jun 30. PMID 7797555
    2. Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae. Barrientos A, et al. EMBO J, 2004 Sep 1. PMID 15306853, Free PMC Article
    3. A Genome-Wide Screen in Saccharomyces cerevisiae Reveals a Critical Role for Oxidative Phosphorylation in Cellular Tolerance to Lithium Hexafluorophosphate. Jin X, et al. Cells, 2021 Apr 13. PMID 33924665, Free PMC Article
    4. Mitochondrial Cytochrome c Oxidase Biogenesis Is Regulated by the Redox State of a Heme-Binding Translational Activator. Soto IC, et al. Antioxid Redox Signal, 2016 Feb 20. PMID 26415097, Free PMC Article
    5. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. McStay GP, et al. FEBS Lett, 2013 Apr 2. PMID 23434581, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial translation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox14p
    NP_013577.1
    • Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      14541..14753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182492.1 → NP_013577.1  TPA: Cox14p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0F6, P39103
      UniProtKB/TrEMBL
      A6ZLT6, B3LLD1, C7GVB0, C8ZE73, G2WJS8, N1NYJ9
      Conserved Domains (1) summary
      pfam14880
      Location:2 → 56
      COX14; Cytochrome oxidase c assembly
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39103.1

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