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    ANY1 Any1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ANY1
    Official Full Name
    Any1p
    Primary source
    SGD:S000004612
    Locus tag
    YMR010W
    See related
    AllianceGenome:SGD:S000004612; FungiDB:YMR010W; VEuPathDB:YMR010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CFS1
    Summary
    Involved in phospholipid translocation and retrograde transport, endosome to Golgi. Located in endosome membrane and trans-Golgi network membrane. Orthologous to human SLC66A2 (solute carrier family 66 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ANY1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (285100..286317)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acireductone dioxygenase (Ni2+-requiring) Neighboring gene hexose transporter HXT2 Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. Zer C, et al. J Biol Chem, 2005 Aug 12. PMID 15967792
    2. A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi functions. Miyasaka M, et al. PLoS One, 2020. PMID 32730286, Free PMC Article
    3. The PQ-loop protein Any1 segregates Drs2 and Neo1 functions required for viability and plasma membrane phospholipid asymmetry. Takar M, et al. J Lipid Res, 2019 May. PMID 30824614, Free PMC Article
    4. Combining multisource information through functional-annotation-based weighting: gene function prediction in yeast. Ray SS, et al. IEEE Trans Biomed Eng, 2009 Feb. PMID 19272921
    5. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Any1 regulates Golgi membrane remodeling through protein-protein interactions rather than a previously proposed scramblase activity.
      Title: The PQ-loop protein Any1 segregates Drs2 and Neo1 functions required for viability and plasma membrane phospholipid asymmetry.
    2. YMR010W, aci-reductone dioxygenase 1, is called Adi1p and is cleaved by Rnt1p
      Title: Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Any1p
    NP_013723.1
    • Protein involved in phospholipid flippase function; null allele suppresses growth and membrane trafficking defects associated with all flippase null alleles; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the endosome and trans-Golgi network; non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      285100..286317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182506.1 → NP_013723.1  TPA: Any1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI4, Q03687
      UniProtKB/TrEMBL
      B3LLR1, B5VPD6, C7GLA9, G2WK61, N1NX55
      Conserved Domains (1) summary
      pfam04193
      Location:252 → 311
      PQ-loop; PQ loop repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03687.1

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