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    STV1 H(+)-transporting V0 sector ATPase subunit a [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STV1
    Official Full Name
    H(+)-transporting V0 sector ATPase subunit a
    Primary source
    SGD:S000004658
    Locus tag
    YMR054W
    See related
    AllianceGenome:SGD:S000004658; FungiDB:YMR054W; VEuPathDB:YMR054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol-4-phosphate binding activity. Contributes to proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in Golgi apparatus and late endosome. Part of vacuolar proton-transporting V-type ATPase, V0 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STV1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (383303..385975)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Far3p Neighboring gene Stb2p Neighboring gene Bub2p Neighboring gene ADP/ATP carrier protein AAC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and localization of an essential transmembrane segment of the proton translocation channel of yeast H+-V-ATPase. Duarte AM, et al. Biochim Biophys Acta, 2007 Feb. PMID 16962559
    2. The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase. Manolson MF, et al. J Biol Chem, 1992 Jul 15. PMID 1385813
    3. Evidence for a conserved 95-120 kDa subunit associated with and essential for activity of V-ATPases. Manolson MF, et al. J Exp Biol, 1992 Nov. PMID 1491220
    4. Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity. Qi J, et al. J Biol Chem, 2007 Aug 24. PMID 17565997, Free PMC Article
    5. STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p. Manolson MF, et al. J Biol Chem, 1994 May 13. PMID 7514599

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STV1 overexpression suppressed the growth defects of both rav1 and rav1vph1, and allowed RAVE-independent assembly of active Stv1p-containing V-ATPases in vacuoles.
      Title: The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast.
    2. This evolutionary intermediate includes an endogenous W(83)KY sorting motif and is sufficient to compete with sorting of the native yeast Stv1p V-ATPase isoform.
      Title: Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar acidification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-transporting V0 sector ATPase subunit a
    NP_013770.1
    • Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      383303..385975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182552.1 → NP_013770.1  TPA: H(+)-transporting V0 sector ATPase subunit a [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZM9, P37296
      UniProtKB/TrEMBL
      A6ZMB4, B3LLU8, C7GL69, G2WKA3, N1NY87
      Conserved Domains (1) summary
      pfam01496
      Location:32 → 885
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37296.2

    Gene LinkOut

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