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    SEN15 Sen15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEN15
    Official Full Name
    Sen15p
    Primary source
    SGD:S000004663
    Locus tag
    YMR059W
    See related
    AllianceGenome:SGD:S000004663; FungiDB:YMR059W; VEuPathDB:YMR059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to tRNA-intron endonuclease activity. Involved in tRNA-type intron splice site recognition and cleavage. Part of tRNA-intron endonuclease complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEN15 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (391099..391485)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ADP/ATP carrier protein AAC1 Neighboring gene ferroxidase FET3 Neighboring gene SAM complex subunit SAM37 Neighboring gene cleavage polyadenylation factor subunit RNA14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Trotta CR, et al. Cell, 1997 Jun 13. PMID 9200603
    2. Exon structure requirements for yeast tRNA ligase. Liu J, et al. Sci China C Life Sci, 1997 Dec. PMID 18726292
    3. The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA. Tsuboi T, et al. J Biol Chem, 2015 Jun 26. PMID 25971974, Free PMC Article
    4. Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria. Yoshihisa T, et al. Mol Biol Cell, 2003 Aug. PMID 12925762, Free PMC Article
    5. Genetic bypass of essential RNA repair enzymes in budding yeast. Cherry PD, et al. RNA, 2018 Mar. PMID 29212664, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to tRNA-intron endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA-type intron splice site recognition and cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-intron endonuclease complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tRNA-intron endonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sen15p
    NP_013775.2
    • Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      391099..391485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182557.1 → NP_013775.2  TPA: Sen15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013775.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZN3, Q04675
      UniProtKB/TrEMBL
      C7GL65, C8ZER1, G2WKA7, N1P082
      Conserved Domains (1) summary
      pfam09631
      Location:9 → 128
      Sen15; Sen15 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04675.2

    Gene LinkOut

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