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    REC114 Rec114p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    REC114
    Official Full Name
    Rec114p
    Primary source
    SGD:S000004740
    Locus tag
    YMR133W
    See related
    AllianceGenome:SGD:S000004740; FungiDB:YMR133W; VEuPathDB:YMR133W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in reciprocal meiotic recombination. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REC114 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (536207..537609)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein RRB1 Neighboring gene Jlp2p Neighboring gene Erg29p Neighboring gene glucose-induced degradation complex subunit GID8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Examination of the intron in the meiosis-specific recombination gene REC114 in Saccharomyces. Malone RE, et al. Mol Gen Genet, 1997 Jul. PMID 9267437
    2. Genetic and molecular analysis of REC114, an early meiotic recombination gene in yeast. Pittman D, et al. Curr Genet, 1993. PMID 8385581
    3. Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. Liu K, et al. Genes Dev, 2023 Jun 1. PMID 37442580, Free PMC Article
    4. Recombination and the progression of meiosis in Saccharomyces cerevisiae. Galbraith AM, et al. Genetics, 1997 Jun. PMID 9177999, Free PMC Article
    5. High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway. Bishop DK, et al. Genes Cells, 1999 Aug. PMID 10526232

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA-driven condensation assembles the meiotic DNA break machinery.
      Title: DNA-driven condensation assembles the meiotic DNA break machinery.
    2. Taken together, we present evidence for three independent ways of regulating Rec114 activity, which likely contribute to meiotic DSBs-homeostasis in maintaining genetically determined levels of breaks.
      Title: Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery.
    3. Mer2, Mei4, and Rec114 form a distinct complex required for double-strand breaks formation.
      Title: Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA double-strand break formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rec114p
    NP_013852.1
    • Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      536207..537609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182634.1 → NP_013852.1  TPA: Rec114p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZV6, P32841
      UniProtKB/TrEMBL
      A6ZMJ3, C7GU85, C8ZEY8, G2WKI4
      Conserved Domains (1) summary
      pfam03525
      Location:12 → 324
      Meiotic_rec114; Meiotic recombination protein rec114
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32841.3

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