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    SPO1 putative carboxylic ester hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPO1
    Official Full Name
    putative carboxylic ester hydrolase
    Primary source
    SGD:S000004957
    Locus tag
    YNL012W
    See related
    AllianceGenome:SGD:S000004957; FungiDB:YNL012W; VEuPathDB:YNL012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phospholipase A2 activity. Involved in meiosis I; spindle pole body duplication; and spore membrane bending pathway. Located in endoplasmic reticulum; nucleus; and prospore membrane. Orthologous to several human genes including PLA2G4C (phospholipase A2 group IVC) and PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPO1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (609686..611665)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pbi2p Neighboring gene translation elongation factor EF-3 Neighboring gene uncharacterized protein Neighboring gene putative phosphoric monoester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SPO1 gene product required for meiosis in yeast has a high similarity to phospholipase B enzymes. Tevzadze GG, et al. Gene, 1996 Oct 24. PMID 8921875
    2. Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence. Verhasselt P, et al. Yeast, 1994 Jul. PMID 7985421
    3. Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae. Tevzadze GG, et al. Chromosoma, 2000. PMID 10855497
    4. SPO71 mediates prospore membrane size and maturation in Saccharomyces cerevisiae. Parodi EM, et al. Eukaryot Cell, 2012 Oct. PMID 22611022, Free PMC Article
    5. The Dysferlin Domain-Only Protein, Spo73, Is Required for Prospore Membrane Extension in Saccharomyces cerevisiae. Okumura Y, et al. mSphere, 2016 Jan-Feb. PMID 27303688, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the SpoMBe pathway of Sma2p and Spo1p involves asymmetric distribution of Sma2p and does not involve a GPI-protein-containing matrix
      Title: The SpoMBe pathway drives membrane bending necessary for cytokinesis and spore formation in yeast meiosis.
    2. A Spo1-dependent, meiosis-specific signaling pathway is required for progression of MI, MII, and spore formation via regulation of the spindle pole body .
      Title: Genetic evidence for a SPO1-dependent signaling pathway controlling meiotic progression in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore-type prospore membrane formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spore membrane bending pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spore membrane bending pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative carboxylic ester hydrolase
    NP_014386.2
    • Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      609686..611665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182851.1 → NP_014386.2  TPA: putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014386.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1G5, P53541
      UniProtKB/TrEMBL
      C8ZFL4, N1NY35
      Conserved Domains (1) summary
      smart00022
      Location:19 → 629
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53541.2

    Gene LinkOut

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