GCD10 tRNA 1-methyladenosine methyltransferase subunit GCD10 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCD10
Official Full Name: tRNA 1-methyladenosine methyltransferase subunit GCD10
Primary source: SGD:S000005006
Locus tag: YNL062C
See related: AllianceGenome:SGD:S000005006; FungiDB:YNL062C; VEuPathDB:YNL062C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TRM6
Summary: Contributes to tRNA (adenine(58)-N1)-methyltransferase activity. Involved in tRNA methylation. Located in nucleus. Part of tRNA (m1A) methyltransferase complex. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCD10 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (508776..510212, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 has been reported.
Title: Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
X-ray diffraction analysis of the TRM6-TRM61 complex were performed in this study. The crystals diffracted to 2.80 A resolution and belonged to the trigonal space group P3(1)21 or P3(2)21, with unit-cell parameters a = b = 139.14, c = 101.62 A
Title: Crystallization and preliminary X-ray diffraction crystallographic study of tRNA m(1)A58 methyltransferase from Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to tRNA (adenine(58)-N1)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA (m1A) methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA (m1A) methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA (m1A) methyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of tRNA (m1A) methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: tRNA 1-methyladenosine methyltransferase subunit GCD10

NP_014337.3

Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

508776..510212 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182900.3 → NP_014337.3 TPA: tRNA 1-methyladenosine methyltransferase subunit GCD10 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014337.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1B8, P41814

UniProtKB/TrEMBL

A6ZS18, B3LNS1, B5VQY2, C8ZGG7, G2WM43, N1NY04

Conserved Domains (1) summary

pfam04189
Location:6 → 324

Gcd10p; Gcd10p family