APC1 anaphase promoting complex subunit 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: APC1
Official Full Name: anaphase promoting complex subunit 1
Primary source: SGD:S000005116
Locus tag: YNL172W
See related: AllianceGenome:SGD:S000005116; FungiDB:YNL172W; VEuPathDB:YNL172W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables molecular adaptor activity. Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic cell cycle phase transition; and protein ubiquitination. Located in nucleus. Part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase/anaphase transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase/anaphase transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

NP_014227.4

Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress

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