GIS2 mRNA-binding translational activator GIS2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GIS2
Official Full Name: mRNA-binding translational activator GIS2
Primary source: SGD:S000005199
Locus tag: YNL255C
See related: AllianceGenome:SGD:S000005199; FungiDB:YNL255C; VEuPathDB:YNL255C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity; single-stranded DNA binding activity; and translation regulator activity. Involved in positive regulation of cytoplasmic translation. Located in P-body and cytoplasmic stress granule. Used to study myotonic dystrophy type 2. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including ZCCHC13 (zinc finger CCHC-type containing 13). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed

NP_014144.1

Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2

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The following sections contain reference sequences that belong to a specific genome build. Explain