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    MSE1 glutamate--tRNA ligase MSE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSE1
    Official Full Name
    glutamate--tRNA ligase MSE1
    Primary source
    SGD:S000005393
    Locus tag
    YOL033W
    See related
    AllianceGenome:SGD:S000005393; FungiDB:YOL033W; VEuPathDB:YOL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glutamate-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSE1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (263475..265085)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA repair ATPase SMC5 Neighboring gene Opi10p Neighboring gene Sil1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
    2. Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion. Rinehart J, et al. Genes Dev, 2005 Mar 1. PMID 15706032, Free PMC Article
    3. CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Ren J, et al. Protein Eng Des Sel, 2008 Nov. PMID 18753194, Free PMC Article
    4. Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins. Margulis NG, et al. Traffic, 2016 Mar. PMID 26650540, Free PMC Article
    5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-tRNA ligase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamyl-tRNA aminoacylation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in mitochondrial glutamyl-tRNA aminoacylation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--tRNA ligase MSE1
    NP_014609.1
    • Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      263475..265085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183287.1 → NP_014609.1  TPA: glutamate--tRNA ligase MSE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W232, P48525, Q08203
      UniProtKB/TrEMBL
      A6ZNH4, B3LJ24, C7GK03, C8ZHT1, N1NVP7
      Conserved Domains (1) summary
      TIGR00464
      Location:44 → 533
      gltX_bact; glutamyl-tRNA synthetase, bacterial family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48525.2

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