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    SAS5 Sas5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAS5
    Official Full Name
    Sas5p
    Primary source
    SGD:S000005739
    Locus tag
    YOR213C
    See related
    AllianceGenome:SGD:S000005739; FungiDB:YOR213C; VEuPathDB:YOR213C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histone acetyltransferase activity. Involved in subtelomeric heterochromatin formation. Located in chromatin. Part of SAS acetyltransferase complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); MLLT3 (MLLT3 super elongation complex subunit); and YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAS5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (744535..745281, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dynamin-related GTPase MGM1 Neighboring gene G protein subunit beta Neighboring gene Spr2p Neighboring gene Aim41p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. Sutton A, et al. J Biol Chem, 2003 May 9. PMID 12626510
    2. Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471696, Free PMC Article
    3. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471697, Free PMC Article
    4. Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes. Miller A, et al. J Biol Chem, 2010 Nov 5. PMID 20813847, Free PMC Article
    5. Nuclear import of the histone acetyltransferase complex SAS-I in Saccharomyces cerevisiae. Schaper S, et al. J Cell Sci, 2005 Apr 1. PMID 15788653

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in subtelomeric heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAS acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAS acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sas5p
    NP_014856.1
    • Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      744535..745281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183632.1 → NP_014856.1  TPA: Sas5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2R9, Q99314
      UniProtKB/TrEMBL
      A6ZP56, B3LJN7, C7GWG9, C8ZGW8, N1NWS5
      Conserved Domains (1) summary
      COG5033
      Location:1 → 245
      TFG3; Transcription initiation factor IIF, auxiliary subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99314.1

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