U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ULA1 Ula1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856104, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ULA1
    Official Full Name
    Ula1p
    Primary source
    SGD:S000005924
    Locus tag
    YPL003W
    See related
    AllianceGenome:SGD:S000005924; FungiDB:YPL003W; VEuPathDB:YPL003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ENR2
    Summary
    Enables NEDD8 activating enzyme activity. Involved in protein neddylation. Predicted to be active in cytoplasm. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ULA1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (552020..553408)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aep3p Neighboring gene lipid-binding protein LSP1 Neighboring gene ESCRT-II subunit protein SNF8 Neighboring gene histone acetyltransferase catalytic subunit HAT1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel protein modification pathway related to the ubiquitin system. Liakopoulos D, et al. EMBO J, 1998 Apr 15. PMID 9545234, Free PMC Article
    2. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza JM, et al. Biochem J, 2004 Jan 15. PMID 14519104, Free PMC Article
    3. Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Lammer D, et al. Genes Dev, 1998 Apr 1. PMID 9531531, Free PMC Article
    4. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article
    5. Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Brooks MA, et al. Structure, 2010 Sep 8. PMID 20826334

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ula1p
    NP_015322.1
    • Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      552020..553408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183817.1 → NP_015322.1  TPA: Ula1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W409, Q12059
      UniProtKB/TrEMBL
      C8ZJ23, N1NW69
      Conserved Domains (1) summary
      cl22428
      Location:2 → 460
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12059.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous