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    VPS28 ESCRT-I subunit protein VPS28 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS28
    Official Full Name
    ESCRT-I subunit protein VPS28
    Primary source
    SGD:S000005986
    Locus tag
    YPL065W
    See related
    AllianceGenome:SGD:S000005986; FungiDB:YPL065W; VEuPathDB:YPL065W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL13; VPT28
    Summary
    Involved in ATP export; protein targeting to membrane; and protein targeting to vacuole. Located in endosome. Part of ESCRT I complex. Orthologous to human VPS28 (VPS28 subunit of ESCRT-I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS28 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (427927..428655)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Htc1p Neighboring gene Rgl1p Neighboring gene putative peptidylprolyl isomerase CWC27 Neighboring gene protein translocase subunit TIM50

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Rieder SE, et al. Mol Biol Cell, 1996 Jun. PMID 8817003, Free PMC Article
    2. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Babst M, et al. Traffic, 2000 Mar. PMID 11208108
    3. Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Boura E, et al. Proc Natl Acad Sci U S A, 2011 Jun 7. PMID 21596998, Free PMC Article
    4. The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Pineda-Molina E, et al. Traffic, 2006 Aug. PMID 16749904
    5. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Katzmann DJ, et al. Cell, 2001 Jul 27. PMID 11511343

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the conformations provide reference points for the structural pathway by which ESCRT-I induces membrane buds.
      Title: Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy.
    2. show that Rim8 coimmunoprecipitates with ESCRT-I subunits Vps23 and Vps28, supporting the idea that binding of Rim8 to Vps23 mediates the association of Rim8 with the ESCRT-I complex.
      Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
    3. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37.
      Title: Structural and functional organization of the ESCRT-I trafficking complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ESCRT-I subunit protein VPS28
    NP_015260.1
    • Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      427927..428655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183879.1 → NP_015260.1  TPA: ESCRT-I subunit protein VPS28 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V0, E9P8X2, P87328, Q02767
      UniProtKB/TrEMBL
      C7GTZ2, G2WPB5, N1NVH7
      Conserved Domains (1) summary
      pfam03997
      Location:40 → 241
      VPS28; VPS28 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02767.1

    Gene LinkOut

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