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    SYH1 Syh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SYH1
    Official Full Name
    Syh1p
    Primary source
    SGD:S000006026
    Locus tag
    YPL105C
    See related
    AllianceGenome:SGD:S000006026; FungiDB:YPL105C; VEuPathDB:YPL105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MYR1
    Summary
    Involved in nuclear pore localization. Located in cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1) and GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SYH1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (352863..355412, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Dpc25p Neighboring gene adenyl-nucleotide exchange factor SSE1 Neighboring gene aspartate--tRNA ligase MSD1 Neighboring gene N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding specificities of the GYF domains from two Saccharomyces cerevisiae paralogs. Georgiev A, et al. Protein Eng Des Sel, 2007 Sep. PMID 17804396
    2. Characterization of MYR1, a dosage suppressor of YPT6 and RIC1 deficient mutants. Georgiev A, et al. Curr Genet, 2008 Apr. PMID 18327588
    3. SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations. Okano A, et al. Biosci Biotechnol Biochem, 2015. PMID 25849478
    4. Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation. Veltri AJ, et al. Elife, 2022 Jul 27. PMID 35894211, Free PMC Article
    5. GYF domain proteomics reveals interaction sites in known and novel target proteins. Kofler M, et al. Mol Cell Proteomics, 2005 Nov. PMID 16120600

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation.
      Title: Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation.
    2. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
      Title: SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear pore localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Syh1p
    NP_015220.1
    • hypothetical protein that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      352863..355412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183919.1 → NP_015220.1  TPA: Syh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3R2, Q02875
      UniProtKB/TrEMBL
      A6ZWE6, B3LKW8, B5VT58, N1NVW6
      Conserved Domains (1) summary
      cd00072
      Location:149 → 205
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02875.1

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