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    MF(ALPHA)1 Mf(Alpha)1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MF(ALPHA)1
    Official Full Name
    Mf(Alpha)1p
    Primary source
    SGD:S000006108
    Locus tag
    YPL187W
    See related
    AllianceGenome:SGD:S000006108; FungiDB:YPL187W; VEuPathDB:YPL187W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cupric ion binding activity and mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MF(ALPHA)1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (193648..194145)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative O-acyltransferase Neighboring gene NADH kinase Neighboring gene Uip4p Neighboring gene Mrn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MF alpha 1 gene of Saccharomyces cerevisiae: genetic mapping and mutational analysis of promoter elements. Flessel MC, et al. Genetics, 1989 Feb. PMID 2659433, Free PMC Article
    2. Probing the functional conformation of the tridecapeptide mating pheromone of Saccharomyces cerevisiae through study of disulfide-constrained analogs. Xue CB, et al. Int J Pept Protein Res, 1996 Mar. PMID 8740961
    3. Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p. Manfredi JP, et al. Mol Cell Biol, 1996 Sep. PMID 8756627, Free PMC Article
    4. Histidine2 of the alpha-factor of Saccharomyces cerevisiae is not essential for binding to its receptor or for biological activity. Levin Y, et al. Biochemistry, 1993 Aug 17. PMID 8394129
    5. Growth rate influences MF alpha 1 promoter activity in MAT alpha Saccharomyces cerevisiae. Kirk N, et al. Appl Microbiol Biotechnol, 1994 Nov. PMID 7765775

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The loss of viability observed in telomerase-deficient haploids and diploids is less severe when both MATa and MATalpha are co-expressed than when a single MAT allele is expressed.
      Title: Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cupric ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mating pheromone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mating pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mating pheromone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mf(Alpha)1p
    NP_015137.1
    • Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      193648..194145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184001.1 → NP_015137.1  TPA: Mf(Alpha)1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015137.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I2, P01149, P25041
      UniProtKB/TrEMBL
      C8ZIJ1, U3N3B0
      Conserved Domains (1) summary
      pfam05436
      Location:1 → 85
      MF_alpha_N; Mating factor alpha precursor N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01149.1

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