GUP2 putative O-acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GUP2
Official Full Name: putative O-acyltransferase
Primary source: SGD:S000006110
Locus tag: YPL189W
See related: AllianceGenome:SGD:S000006110; FungiDB:YPL189W; VEuPathDB:YPL189W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable O-acyltransferase activity. Involved in cellular hyperosmotic salinity response and glycerol transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to several human genes including HHAT (hedgehog acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-acyltransferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular hyperosmotic salinity response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycerol transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

NP_015135.1

Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain