MAK3 peptide alpha-N-acetyltransferase MAK3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MAK3
Official Full Name: peptide alpha-N-acetyltransferase MAK3
Primary source: SGD:S000006255
Locus tag: YPR051W
See related: AllianceGenome:SGD:S000006255; FungiDB:YPR051W; VEuPathDB:YPR051W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NAA30
Summary: Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and regulation of protein localization. Part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MAK3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (664960..665490)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
Title: Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide-methionine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NatC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatC complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptide alpha-N-acetyltransferase MAK3

NP_015376.1

EC 2.3.1.256

Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

664960..665490

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184148.1 → NP_015376.1 TPA: peptide alpha-N-acetyltransferase MAK3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015376.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W458, Q03503

UniProtKB/TrEMBL

A6ZWU1, B3LLA7, B5VTK4, C7GY39, C8ZJ76, G2WPM6, N1P245

Conserved Domains (1) summary

COG0456
Location:26 → 162

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]