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    THI22 putative phosphomethylpyrimidine kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI22
    Official Full Name
    putative phosphomethylpyrimidine kinase
    Primary source
    SGD:S000006325
    Locus tag
    YPR121W
    See related
    AllianceGenome:SGD:S000006325; FungiDB:YPR121W; VEuPathDB:YPR121W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydroxymethylpyrimidine kinase activity and phosphomethylpyrimidine kinase activity. Involved in thiamine biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI22 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (778583..780301)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB5 Neighboring gene tRNA-Cys Neighboring gene Axl1p Neighboring gene high-affinity Cu transporter CTR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. Kawasaki Y, et al. Curr Genet, 2005 Mar. PMID 15614489
    2. Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Llorente B, et al. Mol Microbiol, 1999 Jun. PMID 10383756
    3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Bussey H, et al. Nature, 1997 May 29. PMID 9169875
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydroxymethylpyrimidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphomethylpyrimidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphomethylpyrimidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative phosphomethylpyrimidine kinase
    NP_015446.2
    • Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      778583..780301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184218.2 → NP_015446.2  TPA: putative phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015446.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4C0, Q06490
      UniProtKB/TrEMBL
      A6ZX02, B3LK85, B5VTR1, C7GLI4
      Conserved Domains (2) summary
      COG0351
      Location:44 → 317
      ThiD; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]
      COG0819
      Location:352 → 572
      TenA; Thiaminase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06490.2

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