YLH47 Ylh47p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YLH47
Official Full Name: Ylh47p
Primary source: SGD:S000006329
Locus tag: YPR125W
See related: AllianceGenome:SGD:S000006329; FungiDB:YPR125W; VEuPathDB:YPR125W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MRS7
Summary: Predicted to enable ribosome binding activity. Involved in potassium ion transport; protein insertion into mitochondrial inner membrane from matrix; and proton transmembrane transport. Located in mitochondrial inner membrane. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Dissecting structure and function of the monovalent cation/H[+] antiporters Mdm38 and Ylh47 in Saccharomyces cerevisiae.
Title: Dissecting structure and function of the monovalent cation/H(+) antiporters Mdm38 and Ylh47 in Saccharomyces cerevisiae.
The function of YLH47 was analyzed.
Title: Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_015450.1

Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome