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    shd shade [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shdprovided by FlyBase
    Official Full Name
    shadeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003388
    Locus tag
    Dmel_CG13478
    See related
    AllianceGenome:FB:FBgn0003388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    314a1; CG13478; cyp314a1; Cyp314a1; CYP314A1; Dmel\CG13478; Shade; Shd
    Summary
    Enables ecdysone 20-monooxygenase activity. Involved in several processes, including embryonic development via the syncytial blastoderm; instar larval or pupal development; and oogenesis. Located in mitochondrion. Is expressed in several structures, including dorsal epidermis primordium; embryonic/larval fat body; embryonic/larval midgut; epidermis; and gastric caecum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shd in Genome Data Viewer
    Location:
    70E4-70E4; 3-42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14614458..14622205)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14607558..14615305)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene HGTX Neighboring gene uncharacterized protein Neighboring gene RecQ5 helicase Neighboring gene dally-like Neighboring gene long non-coding RNA:CR45888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Blimp-1 Mediates Tracheal Lumen Maturation in Drosophila melanogaster. Öztürk-Çolak A, et al. Genetics, 2018 Oct. PMID 30082278, Free PMC Article
    2. Steroid signaling in mature follicles is important for Drosophila ovulation. Knapp E, et al. Proc Natl Acad Sci U S A, 2017 Jan 24. PMID 28069934, Free PMC Article
    3. Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development. Russo A, et al. Dev Biol, 2019 Nov 1. PMID 31283922
    4. Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila. Rauschenbach IY, et al. J Comp Physiol B, 2008 Jan. PMID 17703313
    5. A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. Akagi K, et al. Development, 2016 Jul 1. PMID 27226323

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
      Title: A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster.
    2. Examine role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.
      Title: Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysone 20-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysteroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ecdysteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shade
    Names
    CG13478-PB
    CG13478-PC
    CG13478-PD
    cytochrome P450
    ecdysone 20-monooxygenase
    shd-PB
    shd-PC
    shd-PD
    NP_001261843.1
    NP_648709.2
    NP_996074.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14614458..14622205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274914.1 → NP_001261843.1  shade, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T483, Q9VUF8
      UniProtKB/TrEMBL
      M9PI59
      Conserved Domains (1) summary
      cl12078
      Location:63 → 528
      p450; Cytochrome P450

    2. NM_206352.2 → NP_996074.1  shade, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T483, Q9VUF8
      UniProtKB/TrEMBL
      M9PI59
      Conserved Domains (1) summary
      cl12078
      Location:63 → 528
      p450; Cytochrome P450

    3. NM_140452.2 → NP_648709.2  shade, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648709.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUF8
      Related
      FBpp0293243, FBtr0304700
      Conserved Domains (1) summary
      cl12078
      Location:6 → 421
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI59 M9PI59
    Q9VUF8.3 Q9VUF8

    Gene LinkOut

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