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    Ipk2 Inositol phosphate kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ipk2provided by FlyBase
    Official Full Name
    Inositol phosphate kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031267
    Locus tag
    Dmel_CG13688
    See related
    AllianceGenome:FB:FBgn0031267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13688; Dmel\CG13688; dmIpk2; ipk2
    Summary
    Enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and inositol-1,4,5-trisphosphate 6-kinase activity. Involved in imaginal disc development and inositol phosphate biosynthetic process. Located in nucleoplasm. Is expressed in salivary gland. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ipk2 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (573033..574264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (573033..574264, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Notchless Neighboring gene Splicing factor 3b subunit 1 Neighboring gene coiled Neighboring gene Prothoracicotropic hormone Neighboring gene PvuII-PstI homology 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article
    2. Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. Seeds AM, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26647185, Free PMC Article
    3. Cluster-Based Analysis of Retinitis Pigmentosa Modifiers Using Drosophila Eye Size and Gene Expression Data. Amstutz J, et al. Genes (Basel), 2022 Feb 21. PMID 35205430, Free PMC Article
    4. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
    5. PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. Parisi E, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446068, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol tetrakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5-trisphosphate 6-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol phosphate kinase 2
    Names
    CG13688-PA
    Ipk2-PA
    NP_608535.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      573033..574264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134691.2 → NP_608535.1  inositol phosphate kinase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRX9, Q9VPR6
      Related
      FBpp0077734
      Conserved Domains (1) summary
      pfam03770
      Location:100 → 304
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRX9 Q8MRX9
    Q9VPR6 Q9VPR6

    Gene LinkOut

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