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    Ip259 Intronic Protein 259 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34419, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ip259provided by FlyBase
    Official Full Name
    Intronic Protein 259provided by FlyBase
    Primary source
    FLYBASE:FBgn0025366
    Locus tag
    Dmel_CG5277
    See related
    AllianceGenome:FB:FBgn0025366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5277; Dmel\CG5277; IP259
    Summary
    Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human NSA2 (NSA2 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ip259 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10408352..10409610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10408352..10409610)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene uncharacterized protein Neighboring gene Like Sm protein 4 Neighboring gene Ionotropic receptor 31a Neighboring gene Ribosomal protein S27A Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 31E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of the Drosophila ubiquitin-80-amino-acid fusion-protein gene. Barrio R, et al. Biochem J, 1994 Aug 15. PMID 8068011, Free PMC Article
    2. Unique gene organization: alternative splicing in Drosophila produces two structurally unrelated proteins. Mottus RC, et al. Gene, 1997 Oct 1. PMID 9370286
    3. An in vivo RNAi mini-screen in Drosophila cancer models reveals novel potential Wnt targets in liver cancer. Even İ, et al. Turk J Gastroenterol, 2019 Feb. PMID 30541713, Free PMC Article
    4. The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster. Hallier B, et al. PLoS One, 2015. PMID 26252215, Free PMC Article
    5. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, et al. iScience, 2022 Sep 16. PMID 36060064, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intronic protein 259
    Names
    CG5277-PA
    CG5277-PB
    Ip259-PA
    Ip259-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10408352..10409610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058031.5 → NP_477379.1  intronic protein 259, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477379.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76994, Q9VKW7
      Related
      FBpp0079607
      Conserved Domains (1) summary
      cd11381
      Location:4 → 259
      NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)

    2. NM_001273418.1 → NP_001260347.1  intronic protein 259, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76994, Q9VKW7
      Conserved Domains (1) summary
      cd11381
      Location:4 → 259
      NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76994 O76994

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