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    cass cassowary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cassprovided by FlyBase
    Official Full Name
    cassowaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286781
    Locus tag
    Dmel_CG6582
    See related
    AllianceGenome:FB:FBgn0286781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAC-11; Aac11; Api5; bad; BcDNA.LD09852; BcDNA:LD09852; cas; CG6582; Dmel\CG6582; l(2)k06710
    Summary
    Predicted to enable RNA binding activity. Involved in negative regulation of apoptotic process. Predicted to be active in nucleus. Is expressed in adult head and organism. Orthologous to human API5 (apoptosis inhibitor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cass in Genome Data Viewer
    Location:
    36C9-36C10; 2-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17474912..17477888, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17474912..17477888, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bicaudal D Neighboring gene small glutamine-rich tetratricopeptide containing protein Neighboring gene four way stop Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene Glucosidase 2 beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. Rigou P, et al. EMBO J, 2009 Jun 3. PMID 19387494, Free PMC Article
    2. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
    3. dumpy interacts with a large number of genes in the developing wing of Drosophila melanogaster. Carmon A, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473031
    4. A screen to identify Drosophila genes required for integrin-mediated adhesion. Walsh EP, et al. Genetics, 1998 Oct. PMID 9755209, Free PMC Article
    5. The LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression. Huang Y, et al. PLoS One, 2007 Oct 31. PMID 17971870, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cassowary
    Names
    Aac11
    CG6582-PA
    antiapoptosis clone 11
    antiapoptosis clone-11
    apoptosis inhibitor-5
    bladderwrack
    cass-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17474912..17477888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058106.5 → NP_477454.1  cassowary [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V431
      Related
      FBpp0080554
      Conserved Domains (1) summary
      pfam05918
      Location:4 → 505
      API5; Apoptosis inhibitory protein 5 (API5)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V431.1 Q9V431

    Gene LinkOut

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