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    Rbp6 RNA-binding protein 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp6provided by FlyBase
    Official Full Name
    RNA-binding protein 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0260943
    Locus tag
    Dmel_CG32169
    See related
    AllianceGenome:FB:FBgn0260943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE25373; CG14055; CG14056; CG32169; CG6573; Dmel\CG32169; rbp6; rrm6; RRM6
    Summary
    Predicted to enable mRNA binding activity and poly(U) RNA binding activity. Predicted to be involved in regulation of translation and stem cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; female germline cell; ganglia; and neurohemal organ. Orthologous to several human genes including MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbp6 in Genome Data Viewer
    Location:
    73E5-74A1; 3-45 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17058774..17238212, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17051874..17231312, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rogdi Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43433 Neighboring gene AFG3 like matrix AAA peptidase subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency. Eiman MN, et al. Sci Rep, 2024 Jan 2. PMID 38168575, Free PMC Article
    2. RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family. Sutherland JM, et al. Asian J Androl, 2015 Jul-Aug. PMID 25851660, Free PMC Article
    3. Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour. Siddall NA, et al. PLoS One, 2012. PMID 23209605, Free PMC Article
    4. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Markmiller S, et al. Cell, 2018 Jan 25. PMID 29373831, Free PMC Article
    5. α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. Mitchell CL, et al. PLoS One, 2017. PMID 28241077, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 6
    Names
    CG32169-PA
    CG32169-PB
    CG32169-PC
    CG32169-PD
    CG32169-PE
    CG32169-PF
    CG32169-PG
    Rbp6-PA
    Rbp6-PB
    Rbp6-PC
    Rbp6-PD
    Rbp6-PE
    Rbp6-PF
    Rbp6-PG

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17058774..17238212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275050.2 → NP_001261979.1  RNA-binding protein 6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCV2
      Conserved Domains (2) summary
      cd12323
      Location:119 → 192
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:30 → 105
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    2. NM_001259883.2 → NP_001246812.1  RNA-binding protein 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NG33
      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 159
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    3. NM_001104162.4 → NP_001097632.1  RNA-binding protein 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVE5
      Conserved Domains (2) summary
      COG0724
      Location:5 → 84
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    4. NM_001259884.2 → NP_001246813.1  RNA-binding protein 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDB5
      Conserved Domains (2) summary
      COG0724
      Location:5 → 84
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    5. NM_168718.3 → NP_730245.2  RNA-binding protein 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730245.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JNU7, A8JNU8, Q26276, Q8MQZ1, Q9VVE5
      Conserved Domains (2) summary
      cd12323
      Location:119 → 192
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:30 → 105
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    6. NM_001144489.3 → NP_001137961.1  RNA-binding protein 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z063
      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 162
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    7. NM_001104161.3 → NP_001097631.1  RNA-binding protein 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVE5
      Conserved Domains (2) summary
      cd12323
      Location:119 → 192
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:31 → 105
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z063 B7Z063
    M9NDB5 M9NDB5
    M9NG33 M9NG33
    M9PCV2 M9PCV2
    Q9VVE5.3 Q9VVE5

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