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    Tep3 Thioester-containing protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tep3provided by FlyBase
    Official Full Name
    Thioester-containing protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0041181
    Locus tag
    Dmel_CG7068
    See related
    AllianceGenome:FB:FBgn0041181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7068; Dmel\CG7068; dTEPIII; TEP3; TEP3mel; TepIII; TEPIII
    Summary
    Predicted to enable endopeptidase inhibitor activity. Involved in defense response to Gram-positive bacterium and innate immune response. Predicted to be located in extracellular space. Is expressed in anterior-posterior subdivision of organism; crop; embryonic/larval plasmatocyte; larval foregut atrium; and larval labral sensory complex. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tep3 in Genome Data Viewer
    Location:
    28C1-28C1; 2-28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7702805..7710690)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7702805..7710690)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Thioester-containing protein 2 Neighboring gene antisense RNA:CR44990 Neighboring gene transfer RNA:Tyrosine-GTA 1-9 Neighboring gene Neurotransmitter transporter-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
    2. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
    3. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Eleftherianos I, et al. Insects, 2020 Jan 28. PMID 32013030, Free PMC Article
    4. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Lagueux M, et al. Proc Natl Acad Sci U S A, 2000 Oct 10. PMID 11027343, Free PMC Article
    5. Contrasting evolutionary patterns in Drosophila immune receptors. Jiggins FM, et al. J Mol Evol, 2006 Dec. PMID 17103056, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thioester-containing protein 3
    Names
    CG7068-PA
    TEP
    Tep3-PA
    thiolester containing protein III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7702805..7710690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078783.3 → NP_523507.2  Thioester-containing protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523507.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0U4, Q9NFV6, Q9VLY7
      Related
      FBpp0079101
      Conserved Domains (6) summary
      cd02897
      Location:918 → 1203
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:697 → 787
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:124 → 215
      A2M_N; MG2 domain
      pfam07677
      Location:1313 → 1402
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:967 → 1200
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:448 → 573
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFV6 Q9NFV6
    Q9VLY7 Q9VLY7

    Gene LinkOut

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