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    Vps4 Vacuolar protein sorting 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps4provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0283469
    Locus tag
    Dmel_CG6842
    See related
    AllianceGenome:FB:FBgn0283469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3B1; bcDNA:GH02678; BcDNA:GH02678; CG6842; DmBcDNA.GH02678; Dmel\CG6842; dvps4; Dvps4; vps4; Vps4B
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in several processes, including autophagosome maturation; neuron development; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in endosome. Predicted to be part of ESCRT IV complex. Is expressed in adult head; ovary; and spermatozoon. Used to study attention deficit hyperactivity disorder. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A) and VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps4 in Genome Data Viewer
    Location:
    16F1-16F2; 1-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17907692..17911097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17801725..17805130)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glutathione synthetase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Shaker Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neural basis of reward anticipation and its genetic determinants. Jia T, et al. Proc Natl Acad Sci U S A, 2016 Apr 5. PMID 27001827, Free PMC Article
    2. New Insights from Drosophila into the Regulation of EGFR Signaling. Harden N. Methods Mol Biol, 2017. PMID 28791632
    3. Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration. Wang H, et al. Sci Adv, 2019 Feb. PMID 30788439, Free PMC Article
    4. Identification of the Drosophila melanogaster homolog of the human spastin gene. Kammermeier L, et al. Dev Genes Evol, 2003 Aug. PMID 12908108
    5. Depletion of ESCRT ameliorates APP-induced AD-like symptoms in Drosophila. Zhuang L, et al. J Cell Physiol, 2023 Jul. PMID 37183375

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. associations were noted between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila
      Title: Neural basis of reward anticipation and its genetic determinants.
    2. R8the findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism.
      Title: Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation.
    3. dvps4 is a tumour suppressor in Drosophila and that JNK is central to the cell-autonomous phenotypes of endosomal sorting complex required for transport-deficient cells.
      Title: Disruption of Vps4 and JNK function in Drosophila causes tumour growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R8 cell-mediated photoreceptor organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT IV complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 4
    Names
    CG6842-PA
    CG6842-PB
    Vps4-PA
    Vps4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17907692..17911097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298467.1 → NP_001285396.1  vacuolar protein sorting 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285396.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y162
      Conserved Domains (4) summary
      cd02678
      Location:6 → 69
      MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
      pfam09336
      Location:379 → 439
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:323 → 361
      AAA_lid_3; AAA+ lid domain
      cd19521
      Location:126 → 296
      RecA-like_VPS4; ATPase domain of vacuolar protein sorting-associated protein 4

    2. NM_133030.4 → NP_573258.1  vacuolar protein sorting 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y162
      Related
      FBpp0074278
      Conserved Domains (4) summary
      cd02678
      Location:6 → 69
      MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
      pfam09336
      Location:379 → 439
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:323 → 361
      AAA_lid_3; AAA+ lid domain
      cd19521
      Location:126 → 296
      RecA-like_VPS4; ATPase domain of vacuolar protein sorting-associated protein 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y162 Q9Y162

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