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    Ssrp Structure specific recognition protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssrpprovided by FlyBase
    Official Full Name
    Structure specific recognition proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010278
    Locus tag
    Dmel_CG4817
    See related
    AllianceGenome:FB:FBgn0010278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cf5; CG4817; Dmel\CG4817; dSsrp; dSSRP; DssRP; dSSRP1; ssrp; SSRP; SSRP1
    Summary
    Enables chromo shadow domain binding activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including follicle cell of egg chamber development; negative regulation of protein phosphorylation; and positive regulation of actin filament polymerization. Located in cytosol and nucleolus. Part of FACT complex. Colocalizes with polytene chromosome interband and polytene chromosome puff. Is expressed in several structures, including adult head; central brain primordium; ganglia; gut section; and nurse cell. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssrp in Genome Data Viewer
    Location:
    60A2-60A2; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23806361..23809004, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19693884..19696527, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44807 Neighboring gene NTF2-related export protein 1 Neighboring gene pippin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures. Bruhn SL, et al. Nucleic Acids Res, 1993 Apr 11. PMID 8479916, Free PMC Article
    2. Solution structure of the HMG-box domain in the SSRP1 subunit of FACT. Kasai N, et al. J Biomol NMR, 2005 May. PMID 16041486
    3. A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus. Hsu T, et al. Proc Natl Acad Sci U S A, 1993 Jul 15. PMID 7688122, Free PMC Article
    4. A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing. Tettey TT, et al. Cell Rep, 2019 Jun 25. PMID 31242411
    5. Phosphorylated intrinsically disordered region of FACT masks its nucleosomal DNA binding elements. Tsunaka Y, et al. J Biol Chem, 2009 Sep 4. PMID 19605348, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alternatively spliced isoforms control self-renewal in neuroblast lineages
      Title: Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
    2. rapid chromatin transactions during early embryogenesis through the dephosphorylation of some sites in the maternally transmitted dSSRP1
      Title: Phosphorylated intrinsically disordered region of FACT masks its nucleosomal DNA binding elements.
    3. Study shows that the GAGA factor-FACT complex and its binding site just downstream from the white gene are crucial for position effect variegation.
      Title: Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading.
    4. Results report the solution structure of the HMG-box domain in Drosophila SSRP1.
      Title: Solution structure of the HMG-box domain in the SSRP1 subunit of FACT.
    5. results show that FACT, a heterodimer of dSPT16 and dSSRP1, associates with GAGA factor through its dSSRP1 subunit & facilitates chromatin remodeling; interactions between GAGA factor and spt16 implicate the GAGA factor-FACT complex in Hox gene expression
      Title: Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromo shadow domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    structure specific recognition protein
    Names
    CG4817-PA
    Ssrp-PA
    chorion factor
    structure-specific recognition protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23806361..23809004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079106.3 → NP_523830.2  structure specific recognition protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523830.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05344, Q86NM5, Q9W1J4
      UniProtKB/TrEMBL
      B5RJ65
      Related
      FBpp0072151
      Conserved Domains (4) summary
      COG5165
      Location:20 → 499
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      cd13231
      Location:332 → 427
      PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
      pfam00505
      Location:557 → 620
      HMG_box; HMG (high mobility group) box
      pfam03531
      Location:75 → 284
      SSrecog; Structure-specific recognition protein (SSRP1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05344.2 Q05344

    Gene LinkOut

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