Pp2A-29B Protein phosphatase 2A at 29B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pp2A-29Bprovided by FlyBase
Official Full Name: Protein phosphatase 2A at 29Bprovided by FlyBase
Primary source: FLYBASE:FBgn0260439
Locus tag: Dmel_CG17291
See related: AllianceGenome:FB:FBgn0260439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 29B; A/PR65; CG13383; CG17291; CG33297; Dmel\CG17291; dPP2A; dPP2A A; DPR65; Pp2A; PP2A; PP2A 29B; PP2A A; PP2A at 29B; pp2a-29b; pp2A-29B; PP2A-29B; PP2A-A; Pp2A29B; PP2A[A]; PR65
Old locus tag: CG17291
Summary: Predicted to enable protein phosphatase regulator activity. Involved in several processes, including non-membrane-bounded organelle assembly; receptor guanylyl cyclase signaling pathway; and regulation of signal transduction. Located in centriole and cytosol. Part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including adult head; adult midgut; brain; embryonic/larval salivary gland; and female germline cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36 and lung cancer. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha) and PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 29B2-29B2; 2-31 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8366038..8370090)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8366038..8370090)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study show that protein phosphatase 2A (PP2A) is required for the development of structurally normal active zones opposite glutamate receptors. When PP2A is inhibited presynaptically.
Title: PP2A and GSK-3beta act antagonistically to regulate active zone development.
The balance of PAR-1 and PP2A effects on Baz phosphorylation determines neuroblasts polarity.
Title: PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.
B56epsilon is alternatively translated adds a new level of regulation to PP2A holoenzymes
Title: The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.
Dephosphorylation of inactivation no afterpotential D (INAD) protein is catalyzed by PP2A, thereby modulating the fast deactivation of the visual response.
Title: Role of protein phosphatase 2A in regulating the visual signaling in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion, centromeric	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein phosphatase 2A at 29B

Names: 65 kDa regulatory subunit of protein phosphatase; CG17291-PA; CG17291-PB; CG17291-PC; CG17291-PD; CG17291-PE; PP2A 65kD subunit A; Pp2A-29B-PA; Pp2A-29B-PB; Pp2A-29B-PC; Pp2A-29B-PD; Pp2A-29B-PE; protein phosphatase 2A; protein phosphate 2A; regulatory subunit A of type 2A protein phosphatase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8366038..8370090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298819.1 → NP_001285748.1 protein phosphatase 2A at 29B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285748.1

Status: REVIEWED

UniProtKB/TrEMBL

H5V8B8

Conserved Domains (2) summary

sd00044
Location:247 → 271

HEAT; HEAT repeat [structural motif]

pfam13646
Location:175 → 267

HEAT_2; HEAT repeats
NM_001259015.2 → NP_001245944.1 protein phosphatase 2A at 29B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245944.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDI6

Conserved Domains (3) summary

pfam13513
Location:181 → 230

HEAT_EZ; HEAT-like repeat

pfam13646
Location:15 → 115

HEAT_2; HEAT repeats

sd00044
Location:247 → 271

HEAT; HEAT repeat [structural motif]
NM_001032056.3 → NP_001027227.1 protein phosphatase 2A at 29B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027227.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F7, P36179, Q2MGK6, Q5BI19, Q9VLN3

UniProtKB/TrEMBL

M9MQH9

Conserved Domains (2) summary

sd00044
Location:247 → 271

HEAT; HEAT repeat [structural motif]

pfam13646
Location:175 → 267

HEAT_2; HEAT repeats
NM_001032055.3 → NP_001027226.1 protein phosphatase 2A at 29B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027226.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F7, P36179, Q2MGK6, Q5BI19, Q9VLN3

UniProtKB/TrEMBL

M9MQH9

Conserved Domains (2) summary

sd00044
Location:247 → 271

HEAT; HEAT repeat [structural motif]

pfam13646
Location:175 → 267

HEAT_2; HEAT repeats
NM_001032054.3 → NP_001027225.1 protein phosphatase 2A at 29B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027225.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F7, P36179, Q2MGK6, Q5BI19, Q9VLN3

UniProtKB/TrEMBL

M9MQH9

Conserved Domains (2) summary

sd00044
Location:247 → 271

HEAT; HEAT repeat [structural motif]

pfam13646
Location:175 → 267

HEAT_2; HEAT repeats