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    Nap1 Nucleosome assembly protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nap1provided by FlyBase
    Official Full Name
    Nucleosome assembly protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015268
    Locus tag
    Dmel_CG5330
    See related
    AllianceGenome:FB:FBgn0015268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5330; dCAF-4; Dmel\CG5330; dNAP-1; dNap1; dNAP1; nap-1; Nap-1; NAP-1; nap1; NAP1; p56; p56/dCAF-4
    Summary
    Enables histone binding activity. Involved in several processes, including DNA replication-dependent chromatin assembly; nucleosome assembly; and nucleus organization. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gland; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nap1 in Genome Data Viewer
    Location:
    60A9-60A9; 2-105 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23905175..23907294, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19792698..19794817, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lost PHDs of trr Neighboring gene antisense RNA:CR45926 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44806 Neighboring gene kazachoc Neighboring gene uncharacterized protein Neighboring gene Sarco/endoplasmic reticulum Ca(2+)-ATPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter. Sharma N, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523016, Free PMC Article
    2. Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes. Vlijm R, et al. Cell Rep, 2015 Jan 13. PMID 25578730
    3. Histone chaperone-mediated co-expression assembly of tetrasomes and nucleosomes. Okimune KI, et al. FEBS Open Bio, 2021 Nov. PMID 34614293, Free PMC Article
    4. The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression. Livengood JA, et al. Nucleic Acids Res, 2004. PMID 15155851, Free PMC Article
    5. Knockout targeting of the Drosophila nap1 gene and examination of DNA repair tracts in the recombination products. Lankenau S, et al. Genetics, 2003 Feb. PMID 12618400, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleosome assembly protein 1 is a regulator of histone H1 acetylation.
      Title: Nucleosome assembly protein 1 is a regulator of histone H1 acetylation.
    2. show that NAP-1 regulates the transcription of the HeT-A retrotransposon, pointing to a positive regulatory role of NAP-1 in telomere expression
      Title: NAP-1, Nucleosome assembly protein 1, a histone chaperone involved in Drosophila telomeres.
    3. We find that the assembly of H3.3-containing tetrasomes and nucleosomes by the histone chaperone Nucleosome Assembly Protein 1 (NAP1) occurs in an identical manner to that of H3-containing tetrasomes and nucleosomes.
      Title: Comparing the Assembly and Handedness Dynamics of (H3.3-H4)2 Tetrasomes to Canonical Tetrasomes.
    4. We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis
      Title: Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
    5. Data indicate the essential roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in spermatogenesis.
      Title: The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.
    6. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
      Title: The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
    7. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.
      Title: Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.
    8. These findings reveal a unique mechanism in which the DNA-bound Tax/pCREB complex recruits CBP/p300, and together with NAP1, the coactivators cooperate to dramatically reduce nucleosome occupancy at the viral promoter.
      Title: The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter.
    9. Nap-1 functions to help to assemble chromatin into a closed form, as does HP2
      Title: Heterochromatin protein 2 interacts with Nap-1 and NURF: a link between heterochromatin-induced gene silencing and the chromatin remodeling machinery in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm DNA condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm DNA decondensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    nucleosome assembly protein 1
    Names
    CG5330-PA
    CG5330-PB
    CG5330-PC
    Nap1-PA
    Nap1-PB
    Nap1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23905175..23907294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057780.4 → NP_477128.1  nucleosome assembly protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24150, Q9W1G7
      Related
      FBpp0072128
      Conserved Domains (1) summary
      pfam00956
      Location:55 → 321
      NAP; Nucleosome assembly protein (NAP)

    2. NM_001259556.1 → NP_001246485.1  nucleosome assembly protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24150, Q9W1G7
      Conserved Domains (1) summary
      pfam00956
      Location:55 → 321
      NAP; Nucleosome assembly protein (NAP)

    3. NM_001259557.2 → NP_001246486.1  nucleosome assembly protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24150, Q9W1G7
      Conserved Domains (1) summary
      pfam00956
      Location:55 → 321
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24150 Q24150
    Q9W1G7 Q9W1G7

    Gene LinkOut

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